Fig. 1

Quantification of the behavioral activity in rats in vivo. A Rats were injected intravenously through the tail vein with etomidate (1.5 mg/kg), propofol (11.8 mg/kg), lidocaine (3 mg/kg) plus etomidate (1.5 mg/kg). B The trend of behavioral score at different time points in the etomidate, propofol, lidocaine plus etomidate groups. (C) Rats were injected intravenously through the tail vein with etomidate at different dose (1.5 mg/kg, 3.8 mg/kg, 6.0 mg/kg). (D) The trend of behavioral score at different time points in the different dose of etomidate groups (1.5 mg/kg, 3.8 mg/kg, 6.0 mg/kg). *: p < 0.05, **: p < 0.01, ***: p < 0.001 the etomidate group vs. the propofol group; #: p < 0.05, ##: p < 0.01, ###: p < 0.001 the etomidate group vs. the lidocaine plus etomidate group by the two way ANOVA (linear mixed-model) analysis and a post-hoc Bonferroni correction test