Fig. 4

Amount of remimazolam used until loss of consciousness. The amount of remimazolam used from the start of remimazolam administration to loss of consciousness is shown in the box-and-whisker diagram. The two ends of the whiskers indicate the maximum and minimum values, the boxes indicate the first to third quartiles, the line in the box indicates the median value, and the cross in the box indicate the mean value. The doses of remimazolam used were 19.5 ± 4.78 mg, 6.14 ± 1.20 mg, and 12.2 ± 1.20 mg in the continuous infusion group, single bolus dose administration of 0.1 group, and single bolus dose administration of 0.2 group, respectively. Significant differences were found between the continuous infusion group and the single bolus dose administration of 0.1 group, and between the continuous infusion group and the single bolus dose administration of 0.2 group. The difference between the continuous infusion and single bolus dose administration of 0.1 group was significant (p < 0.01)