Fig. 3

Time to loss of consciousness. The box-and-whisker diagram illustrates the time from the start of remimazolam administration to loss of consciousness. The two ends of the whiskers indicate the maximum and minimum values, the boxes indicate the first to third quartiles, the lines in the boxes indicate the median values, and the crosses in the boxes indicate the mean values. Outliers exceeding 1.5 times the quartile range are marked as small black circles. Loss of consciousness was assessed every 10 s. Patients who did not fall asleep within the 180-second study observation period were considered to have fallen asleep at 180 s. The mean times to loss of consciousness were 88.2 ± 16.2 s, 59.5 ± 31.5 s, and 42.6 ± 11.4 s in the continuous infusion group, single bolus dose administration of 0.1 group, and single bolus dose administration of 0.2 group, respectively. A significant difference was found between the single bolus dose administration of 0.1 group and continuous infusion group, and between the continuous infusion group and the single bolus dose administration of 0.2 group (p < 0.01)