Table 3 Outcomes
Fospropofol (n = 30) | Propofol (n = 30) | P value | |
|---|---|---|---|
Primary Outcome | |||
Percentage of time with a RASS score of -4 or -5 without rescue sedation, % | 96.78 ± 0.07 | 98.43 ± 0.04 | 0.273 |
Secondary Outcomes | |||
Successful extubation | 10 (33.3) | 11 (36.7) | > 0.999 |
Ventilator-free hours within 7 days, h | 0.00 (0.00 to 36.75) | 0.00 (0.00 to 30.25) | 0.936 |
Ventilator-free hours within 28 days, h | 58.50 (0.00 to 486.00) | 76.50 (0.00 to 480.00) | 0.963 |
Length of ICU stay within 28 days, days | 5.50 (4.00 to 11.50) | 10.00 (5.75 to 17.75) | 0.091 |
28-day all-cause mortality | 13 (43.3) | 12 (40.0) | > 0.999 |
Safety Outcomes | |||
Hypotension | 18 (60.0) | 18 (60.0) | > 0.999 |
Bradycardia | 2 (6.7) | 0 (0.0) | 0.472 |
Propofol infusion syndrome | 0 (0.0) | 0 (0.0) | - |
Triglyceride at discontinuation of study drug, mmol/l | 1.56 (1.01 to 1.88) | 1.91 (1.47 to 2.60) | 0.056 |
Increase of triglyceride¶, mmol/l | 0.18 (-0.12 to- 0.44) | 0.69 (0.07 to 0.96) | 0.027 |
Hypertriglyceridemia at discontinuation of study drug§ | 6 (20.0) | 13 (43.3) | 0.052 |
Mild hypertriglyceridemia | 2 (6.7) | 5 (16.7) | 0.424 |
Moderate hypertriglyceridemia | 4 (13.3) | 8 (26.7) | 0.197 |
Severe hypertriglyceridemia | 0 (0.0) | 0 (0.0) | - |