Fig. 4
From: Microtubule-modulating drugs alter sensitivity to isoflurane in mice
Paclitaxel treatment shifted isoflurane sensitivity to the right in mice. Mice were treated with 20 mg/kg (i.p.) paclitaxel 3 times a week for four weeks (paclitaxel, n = 11; saline, n = 12). Behavioral tests were performed at ∼ 24 h after end of drug treatment. (A) Paclitaxel treatment marginally but significantly right shifted the LORR curve in mice: paclitaxel, 1.05[1.03, 1.06] vs. saline, 0.98 [0.97, 0.99]. (B, C) At 1.2% isoflurane in 100% oxygen, both induction and emergence latencies were comparable between paclitaxel and saline groups (P = 0.58 and P = 0.34) (Tukey plots)