Fig. 2
From: Microtubule-modulating drugs alter sensitivity to isoflurane in mice
Morphine caused resistance to the anesthetic effects of isoflurane in mice. Mice were treated with 10 mg/kg (i.p.) morphine daily for 14 day (morphine, n = 11; saline, n = 12). Behavioral tests were performed at ∼ 24 h after the drug treatment. (A) Morphine treatment induced a rightward shift of LORR at stepwise increased isoflurane concentrations: morphine, 1.16[1.15, 1.16] vs. saline, 0.97[0.96, 0.98]. (B, C) Consistent with rightward shift of induction dose, mice when subjected to 1.2% isoflurane in 100% oxygen, morphine treated mice had extended induction latency (P = 0.003) and shortened emergence latency (P = 0.02) compared with saline treated mice (Tukey plots)