Fig. 1
From: Microtubule-modulating drugs alter sensitivity to isoflurane in mice
Epothilone D increased sensitivity to isoflurance in mice. Mice were treated with 2 mg/kg (i.p.) epothilone D or saline daily for 14 day (epothilone D, n = 12; saline, n = 12). Behavioral tests were performed at ∼ 24 h after the drug treatment. (A) Epothilone D treatment induced left-ward shift of LORR: EC50: epothilone D, 0.75[0.73, 0.77] vs. saline, 0.97[0.96, 0.98]. (B, C) At 1.2% isoflurane in 100% oxygen, no significant differences were observed in latency time for induction (P = 0.08) or emergence (P = 0.09) between epothilone D and saline treatment groups (Tukey plots)