| Total (n = 4466) | Survivors (n = 3281) | Non-survivors (n = 1185) | P value |
---|---|---|---|---|
Ventilator mode (0–6 h) |  |  |  | 0.143 |
 Assisted | 1530 (34) | 1103 (34) | 427 (36) |  |
 Controlled | 2936 (66) | 2178 (66) | 758 (64) |  |
PEEP (0–6 h) |  |  |  | 0.214 |
 Low PEEP | 3496 (78) | 2584 (79) | 912 (77) |  |
 High PEEP | 970 (22) | 697 (21) | 273 (23) |  |
Ventilator mode (6–12 h) |  |  |  | 0.089 |
 Assisted | 1855 (42) | 1388 (42) | 467 (39) |  |
 Controlled | 2611 (58) | 1893 (58) | 718 (61) |  |
PEEP (6–12 h) |  |  |  | 0.043 |
 Low PEEP | 3183 (71) | 2366 (72) | 817 (69) |  |
 High PEEP | 1283 (29) | 915 (28) | 368 (31) |  |
Ventilator mode (12–18 h) |  |  |  | 0.016 |
 Assisted | 2001 (45) | 1506 (46) | 495 (42) |  |
 Controlled | 2465 (55) | 1775 (54) | 690 (58) |  |
PEEP (12–18 h) |  |  |  | < 0.001 |
 Low PEEP | 3161 (71) | 2369 (72) | 792 (67) |  |
 High PEEP | 1305 (29) | 912 (28) | 393 (33) |  |
Ventilator mode (18–24 h) |  |  |  | < 0.001 |
 Assisted | 2119 (47) | 1616 (49) | 503 (42) |  |
 Controlled | 2347 (53) | 1665 (51) | 682 (58) |  |
PEEP (18–24 h) |  |  |  | < 0.001 |
 Low PEEP | 3195 (72) | 2412 (74) | 783 (66) |  |
 High PEEP | 1271 (28) | 869 (26) | 402 (34) |  |
Fluid in during the first 6Â h (ml/kg) | 8.0 (2.6, 20.5) | 7.7 (2.6, 19.6) | 9.4 (2.8, 22.9) | 0.004 |
Fluid in during the first 12Â h (ml/kg) | 17.7 (7. 6, 37.4) | 17.2 (7.4, 36.6) | 19.5 (8.4, 40.9) | 0.002 |
Fluid in during the first 18 h (ml/kg) | 25.1 (11.8, 48.7) | 24.2 (11.5, 46.4) | 27.0 (12.8, 55.4) | < 0.001 |
Fluid in during the first 24 h (ml/kg) | 31.5 (16.0, 57.9) | 30.2 (15.6, 55.5) | 34.7 (17.3, 69.1) | < 0.001 |
Fluid out during the first 6 h (ml/kg) | 5.0 (2.2, 9.7) | 5.3 (2.5, 10.0) | 4.2 (1.3, 8.6) | < 0.001 |
Fluid out during the first 12 h (ml/kg) | 10.7 (5.7, 18.4) | 11.4 (6.4, 19.0) | 9.0 (4.0, 15.9) | < 0.001 |
Fluid out during the first 18 h (ml/kg) | 16.0 (9.1, 26.4) | 17.0 (10.1, 27.4) | 13.2 (6.3, 23.6) | < 0.001 |
Fluid out during the first 24 h (ml/kg) | 21.8 (12.5, 34.2) | 23.1 (14.0, 35.8) | 17.5 (8.6, 30.4) | < 0.001 |
Fluid balance during the first 6 h (ml/kg) | 2.5 (-3.0, 14.3) | 2.0 (-3.2, 13.1) | 4.0 (-2, 17.3) | < 0.001 |
Fluid balance during the first 12 h (ml/kg) | 6.6 (-4.7, 24.8) | 5.6 (-5.3, 23.1) | 8.9 (-2.7, 30.2) | < 0.001 |
Fluid balance during the first 18 h (ml/kg) | 8.6 (-6.7, 31.1) | 6.8 (-7.7, 27.9) | 13.2 (-3.2, 39.4) | < 0.001 |
Fluid balance during the first 24 h (ml/kg) | 9.6 (-8.5, 34.5) | 7.5 (-10, 31.2) | 16.4 (-4.5, 46.9) | < 0.001 |