Fig. 6

The relationship between fluid balance during the first 6Â h, 12Â h, 18Â h, and 24Â h and hospital mortality for patients with high and low PEEP, respectively. Multivariable regression models were used and interaction effect of PEEP on relationship between fluid balance and hospital mortality were separately explored. The confounders included age, sex, Charlson comorbidity index, score, mode of mechanical ventilation, PEEP, and use of (Supplemental Table 4). CRRT, continuous renal replacement treatment, PEEP positive end-expiratory pressure, SOFA, sequential organ failure assessment