Fig. 5

The relationship between fluid balance during the first 6 h, 12 h, 18 h, and 24 h and hospital mortality for patients with assisted and controlled mechanical ventilation, respectively. Multivariable regression models were used and interaction effect of ventilation mode on relationship between fluid balance and hospital mortality were separately explored. The confounders included age, sex, Charlson comorbidity index, SOFA score, mode of mechanical ventilation, PEEP, and use of CRRT (Supplemental Table 3). CRRT, continuous renal replacement treatment, PEEP positive end-expiratory pressure, SOFA, sequential organ failure assessment