Fig. 4

The relationship between fluid balance during the first 6Â h, 12Â h, 18Â h, and 24Â h and hospital mortality, respectively. Multivariable regression models were used. The confounders included age, sex, Charlson comorbidity index, SOFA score, mode of mechanical ventilation, PEEP, and use of CRRT (Supplemental Table 2). CRRT, continuous renal replacement treatment, PEEP positive end-expiratory pressure, SOFA, sequential organ failure assessment