The role of the sympathetic component of the autonomic nervous system on pain before and after third molar extraction– an observational cohort study

Table 2 Calculation of the analgesic drug score

Treatment	Dose (mg)	NNT	ARR	Classification	Score
Acetaminophen alone	1000	3.5	29%	average	1
Ibuprofen alone	200	2.7	37%	good	2
	400	2.3	43%	good	2
Ibuprofen + acetaminophen	200/500	1.6	63%	very good	3
	400/1000	1.4	71%	very good	3
Ketoprofen alone	50	1.8	56%	good	2
	100	1.6	63%	very good	3
Ketoprofen + acetaminophen	no data			very good	3
Tramadol alone	50	9.1	11%	poor	0,5
	75	8.4	12%	poor	0,5
	100	4.6	22%	average	1
	150	4.2	24%	average	1
Tramadol + acetaminophen	50/?	no data		average	1
	75/650	2.6 to 2.9	34 to 38%	good	2
	100/?	no data		good	2
	150/?	no data		very good	3

The estimated number needed to treat (NNT) for each drug dose or combination has been taken from the literature where the comparison was done vs. placebo in dental surgery (see references in the Methods’ section). Comparison with an analgesic drug score has been made by recalculating the absolute risk reduction (ARR = 1/NNT) on the following basis: 0 if no treatment given; 0.5 for poor analgesia (ARR < 20%, NNT > 5); 1 for average analgesia (ARR 20-to-30%, NNT 3.33-to-5); 2 for good analgesia (ARR 30-to-50%, NNT 2-to-3.33); 3 for very good analgesia (ARR > 50%, NNT < 2); 4 when the three analgesic drug families (acetaminophen + NSAID + opiate) were administered

ISSN: 1471-2253