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Table 3 Primary outcomes and secondary outcomes

From: Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial

Variables

OFA group

n = 82

OBA group

n = 83

Estimated effect (95%CI)

P

Primary outcome

    

 Incidence of PONV during 24 h after surgery

12(14.6%)

25(30.1%)

RR 0.49 (0.26 to 0.90)

0.017

Secondary outcomes

    

 Score of PONV severity during 24 h after surgerya

  

-

0.047

 0

70(85.4%)

58(69.9%)

  

 1–2

9(11.0%)

16(19.3%)

  

 ≥ 3

3(3.6%)

9(10.8%)

  

 QoR-15 at 24 h after surgery

113[107,119]

112[102,117]

MD 1.00 (−3.11 to 5.11)

0.358

Pain scores at 24 h after surgery

   

 at rest

3[2,4]

3[2,3]

MD 1.00 (−3.11 to 5.11)

0.540

 with movement

5[5,6]

6[5,6]

MD −1.00 (−1.43 to −0.57)

0.740

 Pain scores at 48 h after surgery

   

 at rest

1[1,2]

1[1,2]

MD 0.00(−0.43 to 0.43)

0.304

 with movement

3[3,4]

4[3,5]

MD −1.00(−1.43 to −0.57)

0.375

 Distance of 6-MWT at 48 h after surgeryb

305[220,372]

298[210,360]

MD 5.00 (−37.65 to 47.65)

0.545

36-Item Short Form Survey at 180 days after surgeryc

  

 Physical functioning

95[80,100]

95[85, 95]

MD 0.00(−3.43 to 3.43)

0.821

 Role limitations due to physical health

100[100, 100]

100[100, 100]

MD 0.00(−3.43 to 3.43)

0.822

 Role limitations due to emotional problems

100[100, 100]

100[100, 100]

MD 5.00(−0.52 to 10.52)

0.593

 Energy/fatigue

80[75, 90]

75[70, 85]

MD 5.00(−0.52 to 10.52)

0.082

 Emotional well-being

84[80, 88]

84[80, 88]

MD 0.00(−3.46 to 3.46)

0.488

 Social functioning

100[100, 100]

100[100, 100]

MD 5.00(−0.52 to 10.52)

0.934

 Bodily Pain

100[84, 100]

100[84, 100]

MD 0.00(−6.92 to 6.92)

0.833

 General health

67.5[55, 80]

65[50, 75]

MD 0.00(−6.49 to 6.49)

0.150

Exploratory analyses

    

 Length of hospital stay after surgery, day

3[2,3]

3[2,4]

MD 0.00 (−0.68 to 0.68)

0.281

 Length of PACU stay, min

30[25,47]

30[23,49]

MD 0.00 (−8.29 to 8.29)

0.793

  1. Data are median [inter-quartile range], or n (%). aAccessed by simplified postoperative nausea and vomiting impact scale. bThree patients unable to perform the test. cTwo patients were lost to follow up at 180 days. 6-MWT 6-minute walk test, PONV Postoperative nausea and vomiting, Qor-15 Quality of recovery-15 scale, PACU Postoperative anesthesia care unit, OFA Opioid-free anesthesia, OBA Opioid-based anesthesia, PONV Postoperative nausea and vomiting, CI Confidence interval, RR Relative risk