Fig. 3

Transcriptional changes in the hippocampus of young and aging mice post-surgery. A-C Volcano plots of differentially expressed lncRNA, miRNA, mRNA between young surgical and control groups. D-F Volcano plots of differentially expressed lncRNA, miRNA, mRNA between aging surgical and control groups. G-I Differential magnitude of surgery-related changes in lncRNA, miRNA, mRNA between young and aging mice (y-axis = │log2 fold-change│). Whiskers denote the inner fences, circles represent outliers. The P value was calculated with the Wilcoxon matched-pairs signed rank test, ***P < 0.001