Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients

BMC Anesthesiology

Table 6 Pharmacokinetics of ciprofol and propofol

PK parameters	Ciprofol	Propofol	P value
Cmax (μg/mL)	6.02 ± 2.13	15.0 ± 8.20	< 0.001
Tmax (min)	0.18 ± 0.62	0.21 ± 0.75	0.90
t1/2 (h)	3.47 ± 1.85	2.85 ± 2.63	0.46
AUC (0-t) (μg/L*h)	4750 ± 800	11,200 ± 3260	< 0.001
AUC (0-∞) (μg/L*h)	5000 ± 900	12,200 ± 3410	< 0.001
MRT (h)	3.53 ± 0.43	3.27 ± 0.40	0.10
λz (1/h)	0.23 ± 0.07	0.47 ± 0.37	0.02
Vz (L/kg)	3.96 ± 0.84	3.18 ± 1.66	0.32
CL (L/h/kg)	0.83 ± 0.14	1.52 ± 0.48	< 0.001

All values are the mean ± SD
AUC area under the plasma concentration–time curve, Cmax maximum observed concentration, Tmax time to maximum concentration, t1/2 terminal elimination half-life, AUC0-t area under the curve from zero to last time of quantifiable concentration, AUC (0-∞) area under the curve from the zero to infinity time, MRT mean residence time, CL total clearance, Vz volume of distribution based on terminal elimination phase

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