Table 1 Review of current literature on nebulized dexmedetomidine for PDPH
Study | Design | No. of participants | Clinical question | Conclusion |
|---|---|---|---|---|
Kumar et al. (2024) [9] | Prospective | 90 | To compare nDEX versus nebulized fentanyl for the treatment of PDPH in parturients after caesarean section under spinal anesthesia. | The pain scores up to 72 h following nebulization were significantly lower in the DEX group in comparison to the fentanyl group and control group (P < 0.001). Overall additional analgesic requirement in the DEX group was significantly lower in comparison to the other groups (P < 0.001). |
Mowafy et al. (2021) [4] | Prospective | 43 | This study aimed to test the effectiveness of nDEX for conservative management of PDPH and evaluate its cerebral hemodynamic effects transcranial Doppler. | VAS and Lybecker scores were significantly lower in the DEX group. The middle cerebral artery mean flow velocity was significantly lower, and the pulsatility index was considerably higher after nDEX compared to placebo. |
Soliman et al. (2023) [10] | Prospective | 90 | To compare the effectiveness of nDEX versus neostigmine/atropine in the conservative management of PDPH. | VAS was significantly decreased in DEX, and neostigmine/atropine groups compared to the control group at six hours. No patients in the DEX group, but one patient in the neostigmine/atropine group and seven patients in the control group needed an epidural blood patch. |