Table 1 Patient’s baseline characteristics according to the presence of the perioperative administration of methylprednisolone before propensity score matching analysis
Characteristics | Overall (1951) | Perioperative methylprednisolone | P value | SMD | |
|---|---|---|---|---|---|
No (n = 922) | Yes (n = 1029) | ||||
Demographic variables | |||||
 Sex (male/female, %) | 1136/815 (58.2/41.8) | 551/371 (59.8/40.2) | 585/444 (56.9/43.1) | 0.209 | 0.059 |
 Age (65–70/≥70 years, %) | 1121/830 (57.5/42.5) | 514/408 (55.7/44.3) | 607/422 (59.0/41.0) | 0.162 | 0.066 |
 BMI (median (IQR)) | 24.34 (22.41, 26.40) | 24.09 (22.31, 26.21) | 24.54 (22.58, 26.63) | 0.008 | 0.125 |
 Smoking (no/yes, %) | 1179/772 (60.4/39.6) | 560/362 (60.7/39.3) | 619/410 (60.2/39.8) | 0.829 | 0.012 |
Cumulative comorbidities | |||||
 Hypertension (yes/no, %) | 816/1135 (41.8/58.2) | 380/542 (41.2/58.8) | 436/593 (42.4/57.6) | 0.638 | 0.023 |
 Diabetes (yes/no, %) | 429/1522 (22.0/78.0) | 206/716 (22.3/77.7) | 223/806 (21.7/78.3) | 0.762 | 0.016 |
 Coronary heart disease (yes/no, %) | 231/1720 (11.8/88.2) | 112/810 (12.1/87.9) | 119/910 (11.6/88.4) | 0.743 | 0.018 |
 COPD (yes/no, %) | 57/1894 (2.9/97.1) | 27/895 (2.9/97.1) | 30/999 (2.9/97.1) | 0.999 | 0.001 |
Laboratory indicators | |||||
 Serum albumin (g/L) | 41.4 (39.4, 43.6) | 41.3 (39.3, 43.6) | 41.4 (39.4, 43.5) | 0.868 | 0.001 |
 Hemoglobin (g/L) | 137.0 (127.0, 146.0) | 136.0 (127.0, 147.0) | 137.0 (126.0, 146.0) | 0.877 | 0.026 |
 Leukocyte count (×109/L) | 5.9 (4.9, 7.0) | 5.9 (4.9, 7.0) | 5.9 (4.9, 7.0) | 0.870 | 0.007 |
Perioperative variables | |||||
 ASA (I-II/III-IV, %) | 1691/260 (86.7/13.3) | 809/113 (87.7/12.3) | 882/147 (85.7/14.3) | 0.211 | 0.060 |
 Surgical site (%) |  |  |  | 0.283 | 0.072 |
  Left chest | 796 (40.8) | 388 (42.1) | 408 (39.7) |  |  |
  Right chest | 1151 (59.0) | 531 (57.6) | 620 (60.3) |  |  |
  Bilateral | 4 (0.2) | 3 (0.3) | 1 (0.1) |  |  |
 Type of surgery (%) |  |  |  | 0.237 | 0.107 |
  Exploratory operation | 23 (1.2) | 13 (1.4) | 10 (1.0) |  |  |
  Wedge resection | 474 (24.3) | 210 (22.8) | 264 (25.7) |  |  |
  Segmentectomy | 66 (3.4) | 26 (2.8) | 40 (3.9) |  |  |
  Lobectomy | 1332 (68.3) | 643 (69.7) | 689 (67.0) |  |  |
  Pneumonectomy | 56 (2.9) | 30 (3.3) | 26 (2.5) |  |  |
 Lymphadenectomy (yes/no, %) | 1523/428 (78.1/21.9) | 702/220 (76.1/23.9) | 821/208 (79.8/20.2) | 0.059 | 0.088 |
 Open surgery (yes/no, %) | 260/1691 (13.3/86.7) | 174/748 (18.9/81.1) | 86/943 (8.4/91.6) | < 0.001 | 0.310 |
 Surgery duration (< 180/≥180 min, %) | 1312/639 (67.2/32.8) | 613/309 (66.5/33.5) | 699/330 (67.9/32.1) | 0.529 | 0.031 |
 Estimate blood loss (ml) | 50.0 (50.0, 100.0) | 100.0 (50.0, 150.0) | 50.0 (30.0, 100.0) | < 0.001 | 0.111 |
 Colloid (ml) | 500.0 (0.0, 500.0) | 500.0 (0.00, 500.0) | 500.0 (0.0, 500.0) | < 0.001 | 0.305 |
 Crystalloid (ml) | 1100.0 (1100.0, 1600.0) | 1100.0 (1100.0, 1600.0) | 1100.0 (1100.0, 1600.0) | 0.017 | 0.004 |
 Blood transfusion (yes/no, %) | 26/1925 (1.3/98.7) | 10/912 (1.1/98.9) | 16/1013 (1.6/98.4) | 0.480 | 0.041 |
 Tumor size (cm) | 2.5 (1.5, 3.5) | 2.5 (1.6, 3.5) | 2.3 (1.5, 3.2) | 0.008 | 0.109 |
Outcomes | |||||
Postoperative pleural effusion (yes/no, %) | 274/1677 (14.0/86.0) | 177/745 (19.2/80.8) | 97/932 (9.4/90.6) | < 0.001 | 0.432 |
Postoperative pneumonia (yes/no, %) | 188/1763 (9.6/90.4) | 82/840 (8.9/91.1) | 106/923 (10.3/89.7) | 0.330 | 0.043 |