Comparison of the effects of remimazolam and dexmedetomidine on the quality of recovery in functional endoscopic sinus surgery: a randomized clinical trial

Table 3 Recovery profiles after surgery

Variables	Group R (n = 40)	Group D (n = 40)	Group C (n = 40)	P -value
Time to first require rescue analgesia (h)	9.3 (8.9–10.5)^*	10.1 (8.5–11.0)^*	5.5(5.1–6.4)	< 0.001
Number of patients requiring analgesia(n,%)	7 (17.5%)^*	6 (15.0%)^*	18(45.0%)	0.003
Bradycardia(n,%)	0 (0.0)^†	15(37.5)	0 (0.0)^†	< 0.001
Number of patients occurring PONV (n) (0/1/2/3)	37/2/1/0^*	36/2/2/0^*	29/8/2/1	0.024

Variables are presented as the median and interquartile range or number (proportion)
Group R iv. remimazolam, Group D iv. dexmedetomidine, Group C iv. placebo, PONV postoperative nausea or vomiting was assessed by a verbal descriptive scale as 0: no nausea, 1: mild nausea, 2: moderate nausea, 3: severe nausea and vomiting
^*p < 0.05 vs. group C
^†p < 0.05 vs. group D

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