The effect-site concentration of remifentanil blunting endotracheal intubation responses in elderly patients during anesthesia induction with etomidate: a dose-exploration study

Table 2 The changes of the hemodynamic indices (△MAP and △HR) and indices derived from electroencephalogram (△BIS) during endotracheal intubation

Variables	All patients (n = 25)	Positive group (n = 12)	Negative group(n = 13)	P value
△MAP	5. 20 ± 11. 76	11. 83 ± 12. 31	-0. 92 ± 7. 29	0. 004^**
△HR	13. 40 ± 10. 76	22. 33 ± 8. 01	5. 15 ± 4. 38	0. 001^**
△BIS	9. 40 ± 5. 19	11. 92 ± 5. 62	7. 08 ± 3. 57	0. 016^*
△MAP%	5. 94%±13. 08%	13. 63%±13. 48%	-1. 15%±7. 86%	0. 003^**
△HR%	20. 66%±17. 04%	34. 41%±13. 53%	7. 97%±7. 03%	< 0. 001^**
△BIS%	24. 02%±13. 55%	30. 99%±14. 55%	17. 57%±8. 92%	0. 010^*

Data are expressed as mean ± SD. * P<0. 05; **P<0. 01
The absolute value of changes of MAP, HR, and BIS during intubation (ΔMAP, ΔHR, and ΔBIS) were defined as the difference between the baseline and the maximal value within the first 3 min following intubation. The variation amplitude of MAP, HR, and BIS (ΔMAP%, ΔHR%, and ΔBIS%) were defined as ΔMAP, ΔHR, and ΔBIS divided by the baseline value

ISSN: 1471-2253