Incidence of local anesthetic systemic toxicity in patients receiving bupivacaine infiltration analgesia for total joint arthroplasty under general anesthesia: a retrospective single-center study

Table 6 Incidence rates of LAST events in patients receiving sevoflurane or propofol maintenance for unilateral THA

Outcomes	Propofol (n = 91)	Sevoflurane (n = 91)	OR (95% CI)	p value
Major LAST events	3 (3.30)	6 (6.59)	2.12 (1.08–4.65)	0.042*
Seizure	1 (1.09)	4 (4.39)	3.14 (1.68–6.85)	0.016*
Bradycardia or new-onset arrhythmia	3 (3.30)	5 (5.49)	1.45 (0.38–5.51)	0.587
Minor LAST events
Tremor	1(1.10)	6 (6.59)	4.18 (2.24–8.68)	0.024*
Agitation	1 (1.10)	2 (2.19)	1.28 (0.17-10.00)	0.812
Delayed emergence	18 (19.78)	20 (21.97)	1.12 (0.41–1.65)	0.575
Delayed extubation	14 (15.38)	16 (17.58)	0.91 (0.43–1.95)	0.813
Airway insertion	16 (17.58)	17 (18.68)	0.94 (0.46–1.93)	0.872
Oxygen requirement	10 (10.99)	11 (12.08)	1.02 (0.34-2.00)	0.667
Post-operative vomiting	5 (5.49)	6 (6.59)	0.75 (0.24–2.33)	0.623

Data are presented as number (%). Odds ratio and p value were calculated by using univariate logistic regression. *p < 0.05 represented a significant difference between two groups. Abbreviation: CI, confidence interval; LAST, local anesthetic systemic toxicity; OR, odds ratio; THA, total hip arthroplasty

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