Table 2 Characteristics of patients developing severe and major LAST events after LIA
Outcomes | Severe LAST event (n = 4) | Major LAST event (n = 41) |
|---|---|---|
incidence (in the entire cohort) (per 1000) | 3.16 | 32.36 |
Rescue lipid infusion | 4 (100) | 0 |
Seizure | 4 (100) | 11 (26.83) |
Ventricular arrhythmia | 0 | 0 |
Bradycardia or new-onset arrhythmia | 3 (75) | 32 (78.05) |
Other symptoms | Â | Â |
 Delayed emergence | 4 (100) | 17 (41.46) |
 Delayed extubation | 2 (50) | 9 (21.95) |
 Post-operative vomiting | 1 (25) | 6 (14.63) |
Surgery | Â | Â |
 Unilateral THA | 2 (50) | 33 (80.49) |
 Bilateral THA | 2 (50) | 3 (7.32) |
 Unilateral TKA | 0 (0) | 3 (7.32) |
 Bilateral TKA | 0 (0) | 2 (4.88) |
Maintained anesthetics | Â | Â |
 Sevoflurane | 4 (100) | 33 (80.49) |
 Propofol | 0 (0) | 8 (19.51) |
Age (years old) | 52.33 ± 5.51 | 65.14 ± 12.72 |
Male, n (%) | 3 (75) | 9 (21.95) |
BMI (kg/M2) | 23.71 ± 5.02 | 25.31 ± 3.57 |
Chronic diseases | Â | Â |
 Arrhythmia | 1 (25) | 1 (2.44) |
 Liver cirrhosis | 0 (0) | 0 (0) |
 End stage renal disease | 0 (0) | 1 (2.44) |
 CNS disease | 0 (0) | 0 (0) |
Intraoperative blood loss (ml) | 300 ± 100 | 240.24 ± 119.48 |
Duration of anesthesia (min) | 111.33 ± 36.23 | 76.21 ± 21.45 |
Duration of PACU stay (min) | 112.61 ± 24.42 | 85.17 ± 21.68 |
Bupivacaine dose (mg) | 365.67 ± 86.75 | 291.09 ± 60.11 |
Hospitalization (days) | 4.0 ± 1.0 | 3.73 ± 0.26 |
Pain score at 24 h (NRS) | 1.67 ± 0.57 | 1.92 ± 0.65 |