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Table 3 Clinical outcomes

From: Norepinephrine titration in patients with sepsis-induced encephalopathy: cerebral pulsatility index compared to mean arterial pressure guided protocol: randomized controlled trial

Variables

TCD group

MAP group

Test of significance

P value

Serum lactate (mmol/L)

Baseline

 Median (IQR)

3.80 (3.37 – 4.22)

3.80 (3.45 – 4.20)

U 1545.50

0.896

End of NE infusion

 Median (IQR)

2.50 (2.14 – 5.80)

2.65 (2.20 – 5.90)

U 1437.00

0.445

End of ICU stay

 Median (IQR)

1.98 (1.84 – 5.80)

2.0 (1.86 – 5.90)

U 1549.50

0.914

SOFA score

Baseline

 Median (IQR)

4.0 (3.0 – 7.0)

5.0 (3.0 – 8.0)

U 1378.50

0.260

End of ICU stay

 Median (IQR)

2.0 (1.0 – 11.0)

2.0 (1.0 – 11.50)

U 1362.50

0.225

GCS

Baseline on ICU admission

 Median (IQR)

11.0 (10.0 –12.0)

11.0 (9.0 – 12.0)

U 1392.50

0.301

Outcome at ICU discharge

  Median (IQR)

15.0 (8.0 –15.0)

14.0 (5.0 – 15.0)

U 1169.50

0.014*

ICU stay (days)

 Median (IQR)

6.0 (5.0 – 7.0)

6.0 (5.0 – 7.0)

U 1419.50

0.379

ICU mortality 

 Percentage

32.1

44.6

χ2 1.850

0.174

Total NE dosing (mg) 

 Median (IQR)

94.45 (65.85_248.0)

113.5 (60.05_294.0)

U 1384.00

0.284

Duration of NE infusion (days)

 Median (IQR)

4.0 (3.0 – 7.0)

5.0 (3.0 – 7.0)

U 1382.50

0.275

  1. U Mann Whitney test, χ2 Chi square test IQR Inter quartile range, p p value for comparing between the two studied groups
  2. *Statistically significant at p≤ 0.05