Table 2 The association of acetaminophen use with outcomes

Primary outcome

 28-day mortality^†, n (%)

970 (24.9)

987 (34.5)

0.65 (0.60–0.71)

< 0.001

0.69 (0.63–0.75)

< 0.001

Secondary outcomes

 ICU mortality^†, n (%)

574 (14.7)

678 (23.7)

0.50 (0.45–0.56)

< 0.001

0.56 (0.50–0.63)

< 0.001

 In-hospital mortality^†, n (%)

811 (20.8)

836 (29.2)

0.59 (0.53–0.65)

< 0.001

0.62 (0.57–0.69)

< 0.001

 90-day mortality^†, n (%)

1271 (32.7)

1220 (42.7)

0.68 (0.63–0.74)

< 0.001

0.73 (0.68–0.79)

< 0.001

 1-year mortality^†, n (%)

1628 (41.8)

1534 (53.6)

0.69 (0.64–0.73)

< 0.001

0.75 (0.69–0.80)

< 0.001

 Renal recovery^‡, n (%)

1721 (44.2)

1106 (38.7)

1.26 (1.14–1.39)

< 0.001

1.15 (1.04–1.28)

0.007