Table 1 Baseline characteristics
Variables | Total (n = 6752) | Acetaminophen users (n = 3892) | Non-users (n = 2860) | P-value |
|---|---|---|---|---|
Age, year | 68.0 (56, 79) | 67 (56, 78) | 68 (57, 80) | 0.005 |
Sex | ||||
Male | 3888 (57.6) | 2203 (56.6) | 1685 (58.9) | 0.06 |
Female | 2864 (42.4) | 1689 (43.4) | 1175 (41.1) | |
Race | ||||
White | 4330 (64.1) | 2466 (63.4) | 1864 (65.2) | 0.007 |
Black | 699 (10.4) | 381 (9.8) | 318 (11.1) | |
Other | 1723 (25.5) | 1045 (26.8) | 678 (23.7) | |
Weight, kg | 81.1 (68.0, 97.6) | 82.0 (68.8, 99.6) | 80.0 (66.8, 95.7) | < 0.001 |
SOFA | 3 (2, 5) | 3 (2, 5) | 3 (2, 5) | < 0.001 |
Charlson comorbidity index | 6 (4, 8) | 6 (4, 8) | 6 (5, 8) | < 0.001 |
AKI stage | ||||
1 | 4833 (71.6) | 2823 (72.5) | 2010 (70.3) | 0.09 |
2 | 1783 (26.4) | 998 (25.6) | 785 (27.4) | |
3 | 136 (2.0) | 71 (1.8) | 65 (2.3) | |
Comorbidities | ||||
Diabetes mellitus | 2308 (34.2) | 1350 (34.7) | 958 (33.5) | 0.3 |
Chronic pulmonary disease | 2087 (30.9) | 1167 (30.0) | 920 (32.2) | 0.06 |
Congestive heart failure | 2500 (37.0) | 1488 (38.2) | 1012 (35.4) | 0.02 |
Cerebrovascular disease | 767 (11.4) | 480 (12.3) | 287 (10.0) | 0.004 |
Liver disease | 1728 (25.6) | 797 (20.5) | 931 (32.6) | < 0.001 |
Renal disease | 1916 (28.4) | 1069 (27.5) | 847 (29.6) | 0.06 |
Cancer | 912 (13.5) | 454 (11.7) | 458 (16.0) | < 0.001 |
Treatments | ||||
Norepinephrine | 2633 (39.0) | 1547 (39.7) | 1086 (38.0) | 0.1 |
IMV | 3206 (47.5) | 1933 (49.7) | 1273 (44.5) | < 0.001 |
CRRT | 240 (3.6) | 99 (2.5) | 141 (4.9) | < 0.001 |
Vital signs | ||||
Heart rate, beats/minute | 90 (77, 105) | 90 (77, 105) | 90 (77, 104) | 0.9 |
Mean blood pressure, mm Hg | 80 (68, 93) | 80 (69, 93) | 79 (68, 93) | 0.2 |
Respiratory rate, times/minute | 20 (16, 24) | 20 (16, 24) | 19 (16, 24) | 0.01 |
Body temperature, ℃ | 36.7 (36.3, 37.1) | 36.8 (36.4, 37.2) | 36.7 (36.3, 37.0) | < 0.001 |
Laboratory tests | ||||
White blood cell, 109/L | 11.1 (7.3, 16.4) | 11.7 (7.8, 16.8) | 10.5 (6.8, 15.7) | < 0.001 |
Platelet, 109/L | 180 (116, 251) | 186 (126, 254) | 172 (102, 244) | < 0.001 |
Hemoglobin, g/dL | 10.5 (9.0, 12.0) | 10.6 (9.1, 12.3) | 10.3 (8.8, 11.8) | < 0.001 |
Lactate, mmol/L | 1.4 (0.8, 2.2) | 1.4 (0.9, 2.2) | 1.4 (0.7, 2.1) | 0.002 |
Baseline creatinine, mg/dL | 0.8 (0.6, 1.1) | 0.8 (0.6, 1.1) | 0.9 (0.6, 1.1) | < 0.001 |
Outcomes | ||||
28-day mortality | 1957 (29.0) | 970 (24.9) | 987 (34.5) | < 0.001 |
ICU mortality | 1252 (18.5) | 574 (14.7) | 678 (23.7) | < 0.001 |
In-hospital mortality | 1647 (24.4) | 811 (20.8) | 836 (29.2) | < 0.001 |
90-day mortality | 2491 (36.9) | 1271 (32.7) | 1220 (42.7) | < 0.001 |
1-year mortality | 3162 (46.8) | 1628 (41.8) | 1534 (53.6) | < 0.001 |
Renal recovery | 2827 (41.9) | 1721 (44.2) | 1106 (38.7) | < 0.001 |