Figure 2
From: Human physiologically based pharmacokinetic model for propofol
Error in fitting the kinetics following the bolus injection (0 to 60 minutes) using the PBPK parameters determined by fitting the constant infusion kinetics (>60 minutes) assuming no pulmonary sequestration. The solid lines are the PBPK model predictions and the squares are the experimental results of Schnider et. al. [20]. The top row shows the entire time course and the bottom shows the first 60 minutes. Absolute concentration on left and semi-log plot of concentration versus time on right.