Figure 3

The Antinociceptive Effect Measured using Heat. The heat pain threshold was expressed as the mean heat pain threshold of all volunteers (n = 10) when a steady plasma level of the treatment drug had been achieved. These values were then standardised by the threshold value at baseline in order to illustrate the difference in profiles between each treatment arm. The serum concentrations targeted are listed in Table 1 and enumerated on the abscissa using a logarithmic scale.